論文 - 詳細
| RRC ID | 79012 |
|---|---|
| 著者 | Yoshihiro T, Ariyama H, Yamaguchi K, Imajima T, Yamaga S, Tsuchihashi K, Isobe T, Kusaba H, Akashi K, Baba E. |
| タイトル | Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer. |
| ジャーナル | Cancer Sci |
| Abstract |
Microtubule targeting agents (MTAs) such as taxanes are broadly used for the treatment of patients with cancer. Although MTAs are not effective for treatment of colorectal cancer (CRC), preclinical studies suggest that a subset of patients with CRC, especially those with cancers harboring the BRAF mutation, could benefit from such agents. However, two MTAs, eribulin (Eri) and vinorelbine, have shown limited clinical efficacy. Here, we report that insulin-like growth factor 1 receptor (IGF-1R) signaling is involved in Eri resistance. Using CRC cell lines, we showed that Eri induces activation and subsequent translocation of IGF-1R to the nucleus. When the activation and/or nuclear translocation of IGF-1R was inhibited, Eri induced DNA damage and enhanced G2 /M arrest. In a xenograft model using the Eri-resistant SW480 cell line, the combination of Eri and the IGF-1R inhibitor linsitinib suppressed tumor growth more efficiently than either single agent. Thus, our results indicated that combination dosing with Eri and an IGF-1R inhibitor could overcome Eri resistance and offer a therapeutic opportunity in CRC. |
| 巻・号 | 113(12) |
| ページ | 4207-4218 |
| 公開日 | 2022-12-1 |
| DOI | 10.1111/cas.15558 |
| PMID | 36053154 |
| PMC | PMC9746063 |
| MeSH | Animals Cell Line, Tumor Colorectal Neoplasms* / drug therapy Colorectal Neoplasms* / genetics Colorectal Neoplasms* / metabolism DNA Damage Humans Insulin-Like Growth Factor I Protein Kinase Inhibitors / pharmacology Receptor, IGF Type 1* / antagonists & inhibitors |
| IF | 4.966 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COLO-320(RCB1193) |