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  • Search Condition : Filter (MeSH = Ubiquitin-Protein Ligases / metabolism)
Species Resource
Drosophila 3060R-3 Protection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signaling.
Mice 129-Sirt1<tm1Mcby>(RBRC05323) Sirt1-deficiency causes defective protein quality control.
Zebrafish Tg[vsx1:GFP] Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination.
DNA material Genome Network Project Clone IRAL038I16 (HGY095408) Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction.
Medaka TILLING_MUTANT Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement.
Mice MSM/Ms ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner.
DNA material Ax1 CA gfp (RDB01727) Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.
Human and Animal Cells Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.
C.elegans The E3 Ubiquitin Ligase MIB-1 Is Necessary To Form the Nuclear Halo in Caenorhabditis elegans Sperm.
Yeast FY14150 , FY14135 , FY14283 , FY14283 , FY14256 SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.
Drosophila DGRC#109842 , DGRC#109843 The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
Drosophila DGRC#109841 , DGRC#109845 , DGRC#109847 The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
C.elegans Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.
C.elegans RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans.
C.elegans tm1746 MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression.
Drosophila 6190R-3 Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism.
Yeast FY20581 , FY7884 , cdc48 and top2 ts mutant S. pombe strains. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
DNA material pHIS3K-Ptub1 (RDB06564) SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
Drosophila 7425R-1 , 9924R-1 UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.
Human and Animal Cells MKN45(RCB1001) Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.