論文 - 詳細
RRC ID | 36923 |
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著者 | Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M. |
タイトル | DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification. |
ジャーナル | J Biosci Bioeng |
Abstract |
We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active. |
巻・号 | 120(4) |
ページ | 463-6 |
公開日 | 2015-10-1 |
DOI | 10.1016/j.jbiosc.2015.02.009 |
PII | S1389-1723(15)00087-0 |
PMID | 25772439 |
MeSH | 3T3 Cells Animals DNA Damage / drug effects DNA Damage / genetics* Feedback, Physiological / drug effects Humans Mice Mutagenicity Tests* Promoter Regions, Genetic / genetics* Tetracycline / pharmacology Transcription, Genetic / drug effects Transcription, Genetic / genetics* Transcriptional Activation / drug effects Transcriptional Activation / genetics* Transgenes / genetics* Tumor Suppressor Protein p53 / genetics* Up-Regulation / drug effects Up-Regulation / genetics |
IF | 2.366 |
引用数 | 1 |
WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY FOOD SCIENCE & TECHNOLOGY |
リソース情報 | |
ヒト・動物細胞 | 293(RCB1637) |