論文 - 詳細
| RRC ID | 59506 |
|---|---|
| 著者 | Herholz M, Cepeda E, Baumann L, Kukat A, Hermeling J, Maciej S, Szczepanowska K, Pavlenko V, Frommolt P, Trifunovic A. |
| タイトル | KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. |
| ジャーナル | Nat Commun |
| Abstract |
Most manipulations that extend lifespan also increase resistance to various stress factors and environmental cues in a range of animals from yeast to mammals. However, the underlying molecular mechanisms regulating stress resistance during aging are still largely unknown. Here we identify Krüppel-like factor 1 (KLF-1) as a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function. A redox-regulated KLF-1 activation and transfer to the nucleus coincides with the peak of somatic mitochondrial biogenesis that occurs around a transition from larval stage L3 to D1. We further show that KLF-1 activates genes involved in the xenobiotic detoxification programme and identified cytochrome P450 oxidases, the KLF-1 main effectors, as longevity-assurance factors of mitochondrial mutants. Collectively, these findings underline the importance of the xenobiotic detoxification in the mitohormetic, longevity assurance pathway and identify KLF-1 as a central factor in orchestrating this response. |
| 巻・号 | 10(1) |
| ページ | 3323 |
| 公開日 | 2019-7-25 |
| DOI | 10.1038/s41467-019-11275-w |
| PII | 10.1038/s41467-019-11275-w |
| PMID | 31346165 |
| PMC | PMC6658563 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Nucleus / genetics Cell Nucleus / metabolism Female Inactivation, Metabolic Kruppel-Like Transcription Factors / genetics Kruppel-Like Transcription Factors / metabolism* Longevity Male Mitochondria / genetics* Mitochondria / metabolism Xenobiotics / metabolism* |
| IF | 11.878 |
| 引用数 | 0 |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 47 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1110 |