RRC ID 1030
Author Kawamura Y, Fujiwara H, Mishima N, Tanaka Y, Tanimoto A, Ikawa S, Itoh Y, Ezaki T.
Title First Streptococcus agalactiae isolates highly resistant to quinolones, with point mutations in gyrA and parC.
Journal Antimicrob. Agents Chemother.
Abstract Three isolates of Streptococcus agalactiae highly resistant to multiple fluoroquinolones were isolated in Japan. Compared with susceptible strains of S. agalactiae, these quinolone-resistant strains had double point mutations within the quinolone resistance-determining regions of gyrA and parC; Ser-81 was changed to Leu (TCA --> TTA) in the amino acid sequence deduced from gyrA, and Ser-79 was changed to Phe (TCC --> TTC) in the amino acid sequence deduced from parC. Comparative sequence analysis revealed the possibility of gene transfer between S. agalactiae and another beta-hemolytic streptococcus, Streptococcus difficile.
Volume 47(11)
Pages 3605-9
Published 2003-11
PMID 14576126
PMC PMC253773
MeSH Aged Amino Acid Sequence Amino Acid Substitution Anti-Infective Agents / pharmacology* DNA Gyrase / genetics* DNA Topoisomerase IV / genetics* Drug Resistance, Bacterial / genetics Female Gene Transfer, Horizontal Humans Infant, Newborn Male Molecular Sequence Data Point Mutation / genetics* Quinolones / pharmacology* Streptococcal Infections / microbiology Streptococcus agalactiae / drug effects* Streptococcus agalactiae / genetics*
IF 4.256
Times Cited 46
Pathogenic microorganisms GTC 1966 GTC 1967 GTC 2001 GTC 1234 GTC 262 GTC 269 GTC 542 GTC 244 GTC 423? GTC 431 GTC 842 GTC 543? GTC 730 GTC 268? GTC 216 GTC 221