RRC ID 1059
Author Melkusová S, Bujdáková H, Volleková A, Myoken Y, Mikami Y.
Title The efficiency of the benzothiazole APB, the echinocandin micafungin, and amphotericin B in fluconazole-resistant Candida albicans and Candida dubliniensis.
Journal Pharmazie
Abstract This study presents the efficiency of the experimental antifungal agents 6-amino-2-n-pentylthiobenzothiazole (APB) and the echinocandin micafungin, and amphotericin B against fluconazole-resistant Candida albicans and Candida dubliniensis (MIC95 for fluconazole > 64 mg/l). The benzothiazole APB was less active against C. albicans and C. dubliniensis (MIC80 = 8 - 32 mg/l, MIC95 = 16 - 64 mg/l) than amphotericin B, which was efficient in a concentration range from 0.125 to 2 mg/l. However, the efficiency of micafungin was very high with MIC80, and MIC100 < or = 0.031 mg/l.
Volume 59(7)
Pages 573-4
Published 2004-7
PMID 15296100
MeSH Amphotericin B / pharmacology* Antifungal Agents / pharmacology* Candida / drug effects* Candida albicans / drug effects* Candidiasis / microbiology Drug Resistance, Fungal Echinocandins Fluconazole / pharmacology* Humans Lipopeptides Lipoproteins / pharmacology* Micafungin Microbial Sensitivity Tests Peptides, Cyclic / pharmacology* Thiazoles / pharmacology*
IF 1.016
Times Cited 8
WOS Category CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
Resource
Pathogenic microorganisms IFM 48313 IFM 49832 IFM 51757 IFM 52112