RRC ID 1067
著者 Hoshino Y, Mukai A, Yazawa K, Uno J, Ando A, Mikami Y, Fukai T, Ishikawa J, Yamaguchi K.
タイトル Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.
ジャーナル J Antibiot (Tokyo)
Abstract A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.
巻・号 57(12)
ページ 803-7
公開日 2004-12-1
DOI 10.7164/antibiotics.57.803
PMID 15745115
MeSH Anti-Bacterial Agents / chemistry* Magnetic Resonance Spectroscopy Mass Spectrometry Models, Molecular Molecular Structure Nocardia / chemistry* Organometallic Compounds / chemistry* Thiazoles / chemistry* Zinc / chemistry*
IF 2.668
引用数 11
WOS 分野 PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY
リソース情報
病原微生物 IFM 10065