RRC ID |
1067
|
著者 |
Hoshino Y, Mukai A, Yazawa K, Uno J, Ando A, Mikami Y, Fukai T, Ishikawa J, Yamaguchi K.
|
タイトル |
Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.
|
ジャーナル |
J Antibiot (Tokyo)
|
Abstract |
A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.
|
巻・号 |
57(12)
|
ページ |
803-7
|
公開日 |
2004-12-1
|
DOI |
10.7164/antibiotics.57.803
|
PMID |
15745115
|
MeSH |
Anti-Bacterial Agents / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Molecular Structure
Nocardia / chemistry*
Organometallic Compounds / chemistry*
Thiazoles / chemistry*
Zinc / chemistry*
|
IF |
2.668
|
引用数 |
11
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
リソース情報 |
病原微生物 |
IFM 10065 |