論文 - 詳細
| RRC ID | 10741 |
|---|---|
| 著者 | Amin NM, Shi H, Liu J. |
| タイトル | The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development. |
| ジャーナル | Development |
| Abstract |
Forkhead transcription factors play crucial and diverse roles in mesoderm development. In particular, FoxF and FoxC genes are, respectively, involved in the development of visceral/splanchnic mesoderm and non-visceral mesoderm in coelomate animals. Here, we show at single-cell resolution that, in the pseudocoelomate nematode C. elegans, the single FoxF/FoxC transcription factor LET-381 functions in a feed-forward mechanism in the specification and differentiation of the non-muscle mesodermal cells, the coelomocytes (CCs). LET-381/FoxF directly activates the CC specification factor, the Six2 homeodomain protein CEH-34, and functions cooperatively with CEH-34/Six2 to directly activate genes required for CC differentiation. Our results unify a diverse set of studies on the functions of FoxF/FoxC factors and provide a model for how FoxF/FoxC factors function during mesoderm development. |
| 巻・号 | 137(9) |
| ページ | 1451-60 |
| 公開日 | 2010-5-1 |
| DOI | 10.1242/dev.048496 |
| PII | dev.048496 |
| PMID | 20335356 |
| PMC | PMC2853847 |
| MeSH | Animals Animals, Genetically Modified Binding Sites Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Differentiation* Electrophoretic Mobility Shift Assay Enhancer Elements, Genetic / genetics Enhancer Elements, Genetic / physiology Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism* Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology Mesoderm / cytology* Mesoderm / metabolism* Microscopy, Fluorescence Models, Biological Promoter Regions, Genetic / genetics Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 5.611 |
| 引用数 | 14 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm288 |