RRC ID 1100
Author Huaman MC, Yoshinaga K, Suryanatha A, Suarsana N, Kanbara H.
Title Short report: polymorphisms in the chloroquine resistance transporter gene in Plasmodium falciparum isolates from Lombok, Indonesia.
Journal Am J Trop Med Hyg
Abstract The polymorphisms in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) and P. falciparum chloroquine resistance transporter (pfcrt) genes, which are associated with chloroquine resistance, were examined in 48 P. falciparum isolates from uncomplicated malaria patients from the West Lombok District in Indonesia. The point mutation N86Y in pfmdr1 was present in 35.4% of the isolates and mutation K76T in pfcrt was found in all but one of the samples studied. Identified pfcrt haplotypes were mainly identical to the Papua New Guinea type S(agt)VMNT (42 of 48, 87.5%), and a few isolates had the Southeast Asia type CVIET (5 of 48, 10.4%). Moreover, one P. falciparum isolate harbored the K76N mutation, giving rise to the haplotype CVMNN, which was not previously reported in field isolates. Our findings suggest that chloroquine resistance in this area might have the same origin as in Papua New Guinea.
Volume 71(1)
Pages 40-2
Published 2004-7-1
PII 71/1/40
PMID 15238686
MeSH Animals Chloroquine / pharmacology* DNA, Protozoan / chemistry Drug Resistance / genetics* Haplotypes Humans Indonesia Membrane Proteins / genetics* Membrane Transport Proteins Plasmodium falciparum / drug effects Plasmodium falciparum / genetics* Polymorphism, Genetic Protozoan Proteins
IF 2.126
Times Cited 22
Pathogenic microorganisms FCR3 K1 Pf005(3D7 clone)? Pf089(3D7)?