論文 - 詳細
| RRC ID | 11006 |
|---|---|
| 著者 | Matsumoto M, Nakagawa T, Higashi T, Kim TS, Kojima K, Kita T, Sakamoto T, Ito J. |
| タイトル | Innervation of stem cell-derived neurons into auditory epithelia of mice. |
| ジャーナル | Neuroreport |
| Abstract |
This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice for 7 days. Histological analysis demonstrated massive elongation of neurites from embryonic stem cell-derived neurons toward auditory hair cells. Embryonic stem cell-derived neurites were adjacent to or surrounding hair cells, and exhibited expression of synaptophysin, a marker for synaptic vesicles. These findings demonstrate the ability of embryonic stem cell-derived neurons for reinnervation into auditory epithelia, indicating a high potential of embryonic stem cell-derived neurons as transplants for replacing spiral ganglion neurons. |
| 巻・号 | 16(8) |
| ページ | 787-90 |
| 公開日 | 2005-5-31 |
| DOI | 10.1097/00001756-200505310-00001 |
| PII | 00001756-200505310-00001 |
| PMID | 15891570 |
| MeSH | Animals Animals, Newborn Cells, Cultured Coculture Techniques / methods Dyneins / metabolism Embryo, Mammalian Gene Expression Regulation, Developmental / physiology Green Fluorescent Proteins / metabolism Immunohistochemistry / methods Mice Mice, Inbred ICR Myosin VIIa Myosins / metabolism Neurites / physiology Neuroepithelial Cells / physiology* Neurons / physiology* Spiral Ganglion / cytology* Spiral Ganglion / embryology Spiral Ganglion / metabolism Stem Cells / physiology* Synaptophysin / metabolism Tubulin / metabolism |
| IF | 1.394 |
| 引用数 | 24 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-G2/PA6(RCB1127) |