RRC ID 11065
Author Moloney A, Sattelle DB, Lomas DA, Crowther DC.
Title Alzheimer's disease: insights from Drosophila melanogaster models.
Journal Trends Biochem. Sci.
Abstract The power of fruit fly genetics is being deployed against some of the most intractable and economically significant problems in modern medicine, the neurodegenerative diseases. Fly models of Alzheimer's disease can be exposed to the rich diversity of biological techniques that are available to the community and are providing new insights into disease mechanisms, and assisting in the identification of novel targets for therapy. Similar approaches might also help us to interpret the results of genome-wide association studies of human neurodegenerative diseases by allowing us to triage gene "hits" according to whether a candidate risk factor gene has a modifying effect on the disease phenotypes in fly model systems.
Volume 35(4)
Pages 228-35
Published 2010-4
DOI 10.1016/j.tibs.2009.11.004
PII S0968-0004(09)00228-X
PMID 20036556
PMC PMC2856915
MeSH Alzheimer Disease / genetics Alzheimer Disease / physiopathology* Alzheimer Disease / therapy Animals Disease Models, Animal* Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Humans Membrane Proteins / genetics Membrane Proteins / metabolism Membrane Proteins / toxicity Phenotype
IF 15.678
Times Cited 35