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  • Search Condition : Filter (MeSH = Alzheimer Disease / genetics)
Species Resource Title
Human and Animal Cells 409B2(HPS0076) Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells.
Mice RBRC06343 Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.
DNA material Alcadein a-FLAG /pcDNA3.1(+) (RDB19587) , Alcadein b-FLAG /pcDNA3.1(+) (RDB19588) , Alcadein g-FLAG /pcDNA3.1(+) (RDB19589) Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Mice RBRC02370 Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Tau phosphorylation affects its axonal transport and degradation.
Human and Animal Cells PC-12(RCB0009) Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds.
Mice RBRC06334 Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice.
Drosophila Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
Drosophila Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies.
C.elegans tm6026 Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans.
Human and Animal Cells COS-7(RCB0539) TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.
Human and Animal Cells 201B7(HPS0063) Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Mice RBRC01390 Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.
C.elegans tm385 Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans.
C.elegans tm1779 Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
C.elegans tm2034 Toxic role of K+ channel oxidation in mammalian brain.
Human and Animal Cells COS-7(RCB0539) Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.
Drosophila 7899R-2 , 8604R-1 , 8604R-2 , 3546R-1 , 8276R-2 , 8276R-3 , 1090R-1 , 1090R-2 , 10920R-2 , 10920R-3 , ... Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.
Zebrafish Tg(HuC:Kaede)/rw0130a Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development.
C.elegans tm465 , tm776 REST and stress resistance in ageing and Alzheimer's disease.