論文 - 詳細
| RRC ID | 11073 |
|---|---|
| 著者 | Liefke R, Oswald F, Alvarado C, Ferres-Marco D, Mittler G, Rodriguez P, Dominguez M, Borggrefe T. |
| タイトル | Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. |
| ジャーナル | Genes Dev |
| Abstract |
Timely acquisition of cell fates and the elaborate control of growth in numerous organs depend on Notch signaling. Upon ligand binding, the core transcription factor RBP-J activates transcription of Notch target genes. In the absence of signaling, RBP-J switches off target gene expression, assuring the tight spatiotemporal control of the response by a mechanism incompletely understood. Here we show that the histone demethylase KDM5A is an integral, conserved component of Notch/RBP-J gene silencing. Methylation of histone H3 Lys 4 is dynamically erased and re-established at RBP-J sites upon inhibition and reactivation of Notch signaling. KDM5A interacts physically with RBP-J; this interaction is conserved in Drosophila and is crucial for Notch-induced growth and tumorigenesis responses. |
| 巻・号 | 24(6) |
| ページ | 590-601 |
| 公開日 | 2010-3-15 |
| DOI | 10.1101/gad.563210 |
| PII | 24/6/590 |
| PMID | 20231316 |
| PMC | PMC2841336 |
| MeSH | Animals Cell Line Cell Line, Tumor DNA-Binding Proteins / metabolism Drosophila Proteins / metabolism Drosophila melanogaster Histones / metabolism Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism* Jumonji Domain-Containing Histone Demethylases Mice Receptors, Notch / metabolism* Retinoblastoma-Binding Protein 2 / metabolism* Signal Transduction* T-Lymphocytes Ubiquitin-Protein Ligases |
| IF | 9.527 |
| 引用数 | 111 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 9088R-1 9088R-2 |