RRC ID 11074
著者 Terriente-Félix A, López-Varea A, de Celis JF.
タイトル Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development.
ジャーナル Genetics
Abstract The development of the Drosophila melanogaster wing depends on the correct regulation of cell survival, growth, proliferation, differentiation, and pattern formation. These processes, and the genes controlling then, are common to the development of epithelia in many different organisms. To identify additional genes contributing to wing development we have carried out a genetic screen in mosaic wings carrying clones of homozygous mutant cells. We obtained 12 complementation groups corresponding to genes with a proven role in wing formation such as smoothened, thick veins, mothers against dpp, expanded, and fat and 71 new complementation groups affecting the pattern of veins and the size of wing. We mapped one of these groups to the mediator15 gene (med15), a component of the Mediator complex. We show that Med15 and other members of the Mediator complex are required, among other processes, for the transcription of decapentaplegic target genes.
巻・号 185(2)
ページ 671-84
公開日 2010-6-1
DOI 10.1534/genetics.109.113670
PII genetics.109.113670
PMID 20233856
PMC PMC2881146
MeSH Animals Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism Genes Mediator Complex Morphogenesis / genetics* Mutagenesis Phenotype Wings, Animal / growth & development* Wings, Animal / metabolism*
IF 4.015
引用数 16
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ 4184R-4 18780R-3 1245R-1 5546R-1 5057R-1 8491R-2 5465R-1 2254R-1