論文 - 詳細
| RRC ID | 11089 |
|---|---|
| 著者 | Varghese J, Lim SF, Cohen SM. |
| タイトル | Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. |
| ジャーナル | Genes Dev |
| Abstract |
Energy homeostasis depends on insulin signaling in metazoans. Insulin levels reflect the nutritional status of the animal to control levels of circulating sugar and regulate storage of resources in the form of glycogen and fat. Over the past several years, evidence has begun to accumulate that insulin production and secretion, as well as cellular responsiveness to insulin, are subject to regulation by microRNAs. Here we present evidence that miR-14 acts in the insulin-producing neurosecretory cells in the adult Drosophila brain to control metabolism. miR-14 acts in these cells through its direct target, sugarbabe. sugarbabe encodes a predicted zinc finger protein that regulates insulin gene expression in the neurosecretory cells. Regulation of sugarbabe levels by nutrients and by miR-14 combines to allow the fly to manage resource mobilization in a nutritionally variable environment. |
| 巻・号 | 24(24) |
| ページ | 2748-53 |
| 公開日 | 2010-12-15 |
| DOI | 10.1101/gad.1995910 |
| PII | 24/24/2748 |
| PMID | 21159815 |
| PMC | PMC3003191 |
| MeSH | Animals Brain / cytology Brain / metabolism Drosophila / genetics Drosophila / metabolism* Drosophila Proteins / physiology* Energy Metabolism Homeostasis Insulin / biosynthesis Insulin / metabolism* MicroRNAs / physiology* Neurosecretion Transcription Factors / physiology* Zinc Fingers |
| IF | 9.527 |
| 引用数 | 77 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
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