論文 - 詳細
| RRC ID | 11106 |
|---|---|
| 著者 | Toivonen JM, Partridge L. |
| タイトル | Endocrine regulation of aging and reproduction in Drosophila. |
| ジャーナル | Mol Cell Endocrinol |
| Abstract |
Hormonal signals can modulate lifespan and reproductive capacity across the animal kingdom. The use of model organisms such as worms, flies and mice has been fundamentally important for aging research in the discovery of genetic alterations that can extend healthy lifespan. The effects of mutations in the insulin and insulin-like growth factor-like signaling (IIS) pathways are evolutionarily conserved in that they can increase lifespan in all three animal models. Additionally, steroids and other lipophilic signaling molecules modulate lifespan in diverse organisms. Here we shall review how major hormonal pathways in the fruit fly Drosophila melanogaster interact to influence reproductive capacity and aging. |
| 巻・号 | 299(1) |
| ページ | 39-50 |
| 公開日 | 2009-2-5 |
| DOI | 10.1016/j.mce.2008.07.005 |
| PII | S0303-7207(08)00283-9 |
| PMID | 18682271 |
| MeSH | Aging / physiology* Animals Biogenic Amines / physiology Drosophila / physiology* Endocrine System / physiology* Insulin / physiology Models, Animal Models, Biological Reproduction / physiology* Signal Transduction / physiology Somatomedins / physiology |
| IF | 3.871 |
| 引用数 | 98 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |