| RRC ID |
11110
|
| 著者 |
Nagoshi E, Sugino K, Kula E, Okazaki E, Tachibana T, Nelson S, Rosbash M.
|
| タイトル |
Dissecting differential gene expression within the circadian neuronal circuit of Drosophila.
|
| ジャーナル |
Nat Neurosci
|
| Abstract |
Behavioral circadian rhythms are controlled by a neuronal circuit consisting of diverse neuronal subgroups. To understand the molecular mechanisms underlying the roles of neuronal subgroups within the Drosophila circadian circuit, we used cell-type specific gene-expression profiling and identified a large number of genes specifically expressed in all clock neurons or in two important subgroups. Moreover, we identified and characterized two circadian genes, which are expressed specifically in subsets of clock cells and affect different aspects of rhythms. The transcription factor Fer2 is expressed in ventral lateral neurons; it is required for the specification of lateral neurons and therefore their ability to drive locomotor rhythms. The Drosophila melanogaster homolog of the vertebrate circadian gene nocturnin is expressed in a subset of dorsal neurons and mediates the circadian light response. The approach should also enable the molecular dissection of many different Drosophila neuronal circuits.
|
| 巻・号 |
13(1)
|
| ページ |
60-8
|
| 公開日 |
2010-1-1
|
| DOI |
10.1038/nn.2451
|
| PII |
nn.2451
|
| PMID |
19966839
|
| PMC |
PMC3878269
|
| MeSH |
Animals
Animals, Genetically Modified
Behavior, Animal
Biological Clocks / genetics*
Brain / cytology
Circadian Rhythm / genetics*
Drosophila Proteins / genetics
Drosophila melanogaster
Gene Expression Profiling / methods
Gene Expression Regulation / physiology*
Luminescent Proteins / genetics
Nerve Net / metabolism
Neurons / metabolism*
Nuclear Proteins / genetics
Nuclear Proteins / metabolism
Oligonucleotide Array Sequence Analysis / methods
RNA, Messenger / metabolism
Transcription Factors / genetics
Transcription Factors / metabolism
|
| IF |
20.071
|
| 引用数 |
93
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
31299R-6 |
