| RRC ID |
11138
|
| 著者 |
O'Keefe DD, Prober DA, Moyle PS, Rickoll WL, Edgar BA.
|
| タイトル |
Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing.
|
| ジャーナル |
Dev Biol
|
| Abstract |
Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and subcellular localization of the cell adhesion molecule DE-cadherin/Shotgun (Shg) in the differentiating wing epithelium. High Ras activity in presumptive vein cells directs the apical localization of Shg containing adherens junctions, whereas low Ras activity in intervein cells allows Shg to relocalize basally. These alterations in Shg-mediated adhesion control cell shape changes that are essential for vein morphogenesis. While Decapentaplegic (Dpp) acts downstream of Ras to maintain vein cell identity in the pupal wing, our results indicate that Ras controls Shg localization via a Dpp-independent mechanism. Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology.
|
| 巻・号 |
311(1)
|
| ページ |
25-39
|
| 公開日 |
2007-11-1
|
| DOI |
10.1016/j.ydbio.2007.08.003
|
| PII |
S0012-1606(07)01245-6
|
| PMID |
17888420
|
| PMC |
PMC2128780
|
| MeSH |
Animals
Cadherins / analysis
Cadherins / metabolism*
Drosophila / embryology*
Drosophila / metabolism
Drosophila Proteins / analysis
Drosophila Proteins / metabolism*
ErbB Receptors / metabolism*
Mitogen-Activated Protein Kinase Kinases / metabolism
Morphogenesis
Signal Transduction
Veins / cytology
Veins / embryology
Wings, Animal / blood supply
Wings, Animal / embryology
ras Proteins / metabolism*
|
| IF |
2.896
|
| 引用数 |
24
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
|
