論文 - 詳細
| RRC ID | 11155 |
|---|---|
| 著者 | Brun S, Vidal S, Spellman P, Takahashi K, Tricoire H, Lemaitre B. |
| タイトル | The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. |
| ジャーナル | Genes Cells |
| Abstract |
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila. |
| 巻・号 | 11(4) |
| ページ | 397-407 |
| 公開日 | 2006-4-1 |
| DOI | 10.1111/j.1365-2443.2006.00953.x |
| PII | GTC953 |
| PMID | 16611243 |
| MeSH | Animals Drosophila / genetics* Drosophila / immunology* Gene Expression Profiling* Insect Proteins / drug effects Insect Proteins / genetics* Insect Proteins / immunology JNK Mitogen-Activated Protein Kinases / immunology MAP Kinase Kinase Kinase 1 / immunology MAP Kinase Kinase Kinase 1 / pharmacology* Oligonucleotide Array Sequence Analysis / methods Oxidative Stress / drug effects Oxidative Stress / physiology RNA, Messenger / drug effects RNA, Messenger / genetics RNA, Messenger / immunology STAT Transcription Factors / immunology Sepsis / enzymology* Sepsis / genetics Signal Transduction / immunology Time Factors Up-Regulation |
| IF | 1.655 |
| 引用数 | 53 |
| WOS 分野 | GENETICS & HEREDITY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | 7717R-1 7717R-2 |