| RRC ID |
11155
|
| 著者 |
Brun S, Vidal S, Spellman P, Takahashi K, Tricoire H, Lemaitre B.
|
| タイトル |
The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila.
|
| ジャーナル |
Genes Cells
|
| Abstract |
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila.
|
| 巻・号 |
11(4)
|
| ページ |
397-407
|
| 公開日 |
2006-4-1
|
| DOI |
10.1111/j.1365-2443.2006.00953.x
|
| PII |
GTC953
|
| PMID |
16611243
|
| MeSH |
Animals
Drosophila / genetics*
Drosophila / immunology*
Gene Expression Profiling*
Insect Proteins / drug effects
Insect Proteins / genetics*
Insect Proteins / immunology
JNK Mitogen-Activated Protein Kinases / immunology
MAP Kinase Kinase Kinase 1 / immunology
MAP Kinase Kinase Kinase 1 / pharmacology*
Oligonucleotide Array Sequence Analysis / methods
Oxidative Stress / drug effects
Oxidative Stress / physiology
RNA, Messenger / drug effects
RNA, Messenger / genetics
RNA, Messenger / immunology
STAT Transcription Factors / immunology
Sepsis / enzymology*
Sepsis / genetics
Signal Transduction / immunology
Time Factors
Up-Regulation
|
| IF |
1.655
|
| 引用数 |
53
|
|
WOS 分野
|
GENETICS & HEREDITY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
7717R-1
7717R-2 |
