論文 - 詳細
| RRC ID | 11245 |
|---|---|
| 著者 | Fujii T, Abe H, Katsuma S, Shimada T. |
| タイトル | Identification and characterization of the fusion transcript, composed of the apterous homolog and a putative protein phosphatase gene, generated by 1.5-Mb interstitial deletion in the vestigial (Vg) mutant of Bombyx mori. |
| ジャーナル | Insect Biochem Mol Biol |
| Abstract |
The vestigial (Vg) mutant is a Z-linked mutant that causes vestigial wings in the silkworm, Bombyx mori. We have previously reported a 1.5-Mb interstitial deletion on the Z chromosome bearing the Vg mutation (Z(Vg) chromosome). In this study, we found that exons 3-8 of a gene named Bmptp-Z encoding a putative tyrosine-specific protein phosphatase are deleted by the 1.5-Mb interstitial deletion. We found that a gene encoding the Bombyx homolog of Drosophila Apterous (BmAp-A) protein is located 4.5 kb downstream of the distal breakpoint of the 1.5-Mb interstitial deletion. Moreover, an in-frame fusion transcript composed of the 5' part of Bmptp-Z and the 3' part of Bmap-A is generated specific to the Z(Vg) chromosome. Effects of the in-frame fusion transcript on the vestigial phenotype are discussed. |
| 巻・号 | 41(5) |
| ページ | 306-12 |
| 公開日 | 2011-5-1 |
| DOI | 10.1016/j.ibmb.2011.01.007 |
| PII | S0965-1748(11)00024-5 |
| 解説 | Vg(痕跡翅）の原因遺伝子は、Bmap-Aである。Bmap-Aは、ショウジョウバエのapterousのカイコホモログである。Vg系統(u01)のZ染色体には、1.8 Mbの中間部欠失が存在する。この欠失が原因で、通常は1.8 Mb離れている二つの遺伝子(Bmptp-ZとBmap-A)から融合転写産物が生じる。 |
| PMID | 21296154 |
| MeSH | Amino Acid Sequence Animals Base Sequence Bombyx / anatomy & histology Bombyx / genetics* Chromosome Breakpoints Chromosome Mapping Drosophila Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Exons Gene Expression Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Insect Proteins / genetics* Insect Proteins / metabolism LIM-Homeodomain Proteins Molecular Sequence Data Mutation Nuclear Proteins / genetics* Nuclear Proteins / metabolism Phenotype Phosphoprotein Phosphatases / genetics Phosphoprotein Phosphatases / metabolism* RNA, Messenger / analysis RNA, Messenger / biosynthesis Recombinant Fusion Proteins / genetics* Recombinant Fusion Proteins / metabolism Sequence Alignment Sequence Deletion Sequence Homology, Amino Acid Sex Chromosomes / physiology Transcription Factors / genetics Transcription Factors / metabolism* Wings, Animal / anatomy & histology |
| IF | 3.827 |
| 引用数 | 1 |
| WOS 分野 | ENTOMOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| カイコ | u01 |