RRC ID 1154
Author Chibana H, Uno J, Cho T, Mikami Y.
Title Mutation in IRO1 tightly linked with URA3 gene reduces virulence of Candida albicans.
Journal Microbiol. Immunol.
Abstract Gene deletion in the pathogenic fungus Candida albicans has relied heavily on a URA3 cassette and a recipient delta ura3 strain CAI4. The IRO1 gene adjacent to URA3 was inadvertently deleted during construction of CAI4. We report here that a mutation in IRO1 reduces virulence of C. albicans.
Volume 49(10)
Pages 937-9
Published 2005
PII JST.JSTAGE/mandi/49.937
PMID 16237272
MeSH Animals Candida albicans / growth & development Candida albicans / pathogenicity* Candidiasis / microbiology Disease Models, Animal Fungal Proteins / genetics* Fungal Proteins / physiology Gene Deletion Mice Mice, Inbred BALB C Mutation Survival Analysis Transcription Factors / genetics* Transcription Factors / physiology Virulence / genetics*
IF 1.335
Times Cited 11
Pathogenic microorganisms IFM 46932 C. albicans?