論文 - 詳細
| RRC ID | 11588 |
|---|---|
| 著者 | Chihara T, Luginbuhl D, Luo L. |
| タイトル | Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. |
| ジャーナル | Nat Neurosci |
| Abstract |
We identified a mutation in Aats-gly (also known as gars or glycyl-tRNA synthetase), the Drosophila melanogaster ortholog of the human GARS gene that is associated with Charcot-Marie-Tooth neuropathy type 2D (CMT2D), from a mosaic genetic screen. Loss of gars in Drosophila neurons preferentially affects the elaboration and stability of terminal arborization of axons and dendrites. The human and Drosophila genes each encode both a cytoplasmic and a mitochondrial isoform. Using additional mutants that selectively disrupt cytoplasmic or mitochondrial protein translation, we found that cytoplasmic protein translation is required for terminal arborization of both dendrites and axons during development. In contrast, disruption of mitochondrial protein translation preferentially affects the maintenance of dendritic arborization in adults. We also provide evidence that human GARS shows equivalent functions in Drosophila, and that CMT2D causal mutations show loss-of-function properties. Our study highlights different demands of protein translation for the development and maintenance of axons and dendrites. |
| 巻・号 | 10(7) |
| ページ | 828-37 |
| 公開日 | 2007-7-1 |
| DOI | 10.1038/nn1910 |
| PII | nn1910 |
| PMID | 17529987 |
| MeSH | Animals Axons / physiology* COS Cells Chlorocebus aethiops Cloning, Molecular Cytoplasm / metabolism* DNA / genetics Dendrites / physiology* Drosophila Genetic Vectors Glycine-tRNA Ligase / genetics* Glycine-tRNA Ligase / physiology* Humans Mitochondria / metabolism* Mushroom Bodies / physiology Mushroom Bodies / ultrastructure Mutation, Missense / physiology Neurons / physiology Neurons / ultrastructure Phenotype Point Mutation / genetics Point Mutation / physiology Protein Biosynthesis / physiology* |
| IF | 20.071 |
| 引用数 | 72 |
| WOS 分野 | NEUROSCIENCES |
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