| RRC ID |
11591
|
| 著者 |
Hughes CL, Thomas JB.
|
| タイトル |
A sensory feedback circuit coordinates muscle activity in Drosophila.
|
| ジャーナル |
Mol Cell Neurosci
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| Abstract |
Drosophila larval crawling is a simple behavior that allows us to dissect the functions of specific neurons in the intact animal and explore the roles of genes in the specification of those neurons. By inhibiting subsets of neurons in the PNS, we have found that two classes of multidendritic neurons play a major role in larval crawling. The bipolar dendrites and class I mds send a feedback signal to the CNS that keeps the contraction wave progressing quickly, allowing smooth forward movement. Genetic manipulation of the sensory neurons suggests that this feedback depends on proper dendritic morphology and axon pathfinding to appropriate synaptic target areas in the CNS. Our data suggest that coordination of muscle activity in larval crawling requires feedback from neurons acting as proprioceptors, sending a "mission accomplished" signal in response to segment contraction, and resulting in rapid relaxation of the segment and propagation of the wave.
|
| 巻・号 |
35(2)
|
| ページ |
383-96
|
| 公開日 |
2007-6-1
|
| DOI |
10.1016/j.mcn.2007.04.001
|
| PII |
S1044-7431(07)00086-3
|
| PMID |
17498969
|
| PMC |
PMC1978164
|
| MeSH |
Animals
Animals, Genetically Modified
Behavior, Animal
Dendrites / physiology
Drosophila
Drosophila Proteins / genetics
Embryo, Nonmammalian
Feedback*
Green Fluorescent Proteins / biosynthesis
Models, Biological
Movement / physiology*
Muscles / physiology*
Nerve Net / physiology*
Neurons, Afferent / cytology
Neurons, Afferent / physiology*
Videotape Recording
|
| IF |
3.182
|
| 引用数 |
118
|
|
WOS 分野
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NEUROSCIENCES
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| リソース情報 |
| ショウジョウバエ |
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