Reference - Detail
| RRC ID | 11594 |
|---|---|
| Author | Koana T, Okada MO, Ogura K, Tsujimura H, Sakai K. |
| Title | Reduction of background mutations by low-dose X irradiation of Drosophila spermatocytes at a low dose rate. |
| Journal | Radiat Res |
| Abstract |
A sex-linked recessive lethal mutation assay was performed in Drosophila melanogaster using immature spermatocytes and spermatogonia irradiated with X rays at a high or low dose rate. The mutation frequency in the sperm irradiated with a low dose at a low dose rate was significantly lower than that in the sham-irradiated group, whereas irradiation with a high dose resulted in a significant increase in the mutation frequency. It was obvious that the dose-response relationship was not linear, but rather was U-shaped. When mutant germ cells defective in DNA excision repair were used instead of wild-type cells, low-dose irradiation at a low dose rate did not reduce the mutation frequency. These observations suggest that error-free DNA repair functions were activated by low dose of low-dose-rate radiation and that this repaired spontaneous DNA damage rather than the X-ray-induced damage, thus producing a practical threshold. |
| Volume | 167(2) |
| Pages | 217-21 |
| Published | 2007-2-1 |
| DOI | 10.1667/rr0705.1 |
| PMID | 17390729 |
| MeSH | Animals Chromosome Mapping Crosses, Genetic DNA Damage DNA Repair Dose-Response Relationship, Radiation Drosophila / genetics* Drosophila / radiation effects* Female Genes, Recessive Male Mutation* Spermatocytes / radiation effects* Spermatozoa / radiation effects* X-Rays* |
| IF | 2.657 |
| Times Cited | 29 |
| WOS Category | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOLOGY BIOPHYSICS |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |