論文 - 詳細
| RRC ID | 11639 |
|---|---|
| 著者 | Ohayon D, Pattyn A, Venteo S, Valmier J, Carroll P, Garces A. |
| タイトル | Zfh1 promotes survival of a peripheral glia subtype by antagonizing a Jun N-terminal kinase-dependent apoptotic pathway. |
| ジャーナル | EMBO J |
| Abstract |
In Drosophila subperineurial glia (SPG) ensheath and insulate the nerve. SPG is under strict cell cycle and survival control because cell division or death of such a cell type would compromise the integrity of the blood-nerve barrier. The mechanisms underlying the survival of SPG remain unknown. Here, we show that the embryonic peripheral glia expresses the Zfh1 transcription factor, and in zfh1 mutants a particular SPG subtype, ePG10, undergoes apoptosis. Our findings show that in ePG10, Zfh1 represses the pro-apoptotic RHG-motif gene reaper in a cell-autonomous manner. Zfh1 also blocks the activation of the Jun N-terminal kinase (JNK) pathway, and reducing or enhancing JNK signalling in zfh1 mutants prevents or promotes ePG10 apoptosis. Our study shows a novel function for Zfh1 as an anti-apoptotic molecule and uncovers a cryptic JNK-dependent apoptotic programme in ePG10, which is normally blocked by Zfh1. We propose that, in cells such as SPG that do not undergo self-renewal and survive long periods, transcriptional control of RHG-motif gene expression together with fine tuning of JNK signalling is crucial for cell survival. |
| 巻・号 | 28(20) |
| ページ | 3228-43 |
| 公開日 | 2009-10-21 |
| DOI | 10.1038/emboj.2009.247 |
| PII | emboj2009247 |
| PMID | 19745814 |
| PMC | PMC2771085 |
| MeSH | Animals Apoptosis / genetics Apoptosis / physiology* Blotting, Western Cell Differentiation / genetics Cell Differentiation / physiology Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / enzymology Drosophila melanogaster / metabolism Drosophila melanogaster / physiology* Inhibitor of Apoptosis Proteins / genetics Inhibitor of Apoptosis Proteins / physiology JNK Mitogen-Activated Protein Kinases / genetics JNK Mitogen-Activated Protein Kinases / physiology* Neuroglia / cytology* Neuroglia / metabolism* Peripheral Nervous System / metabolism Repressor Proteins / genetics Repressor Proteins / physiology* Signal Transduction / genetics Signal Transduction / physiology |
| IF | 9.889 |
| 引用数 | 10 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |