論文 - 詳細
| RRC ID | 11678 |
|---|---|
| 著者 | Pauls D, Selcho M, Gendre N, Stocker RF, Thum AS. |
| タイトル | Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin. |
| ジャーナル | J Neurosci |
| Abstract |
Insect mushroom bodies are required for diverse behavioral functions, including odor learning and memory. Using the numerically simple olfactory pathway of the Drosophila melanogaster larva, we provide evidence that the formation of appetitive olfactory associations relies on embryonic-born intrinsic mushroom body neurons (Kenyon cells). The participation of larval-born Kenyon cells, i.e., neurons that become gradually integrated in the developing mushroom body during larval life, in this task is unlikely. These data provide important insights into how a small set of identified Kenyon cells can store and integrate olfactory information in a developing brain. To investigate possible functional subdivisions of the larval mushroom body, we anatomically disentangle its input and output neurons at the single-cell level. Based on this approach, we define 10 subdomains of the larval mushroom body that may be implicated in mediating specific interactions between the olfactory pathway, modulatory neurons, and neuronal output. |
| 巻・号 | 30(32) |
| ページ | 10655-66 |
| 公開日 | 2010-8-11 |
| DOI | 10.1523/JNEUROSCI.1281-10.2010 |
| PII | 30/32/10655 |
| PMID | 20702697 |
| PMC | PMC6634688 |
| MeSH | Animals Animals, Genetically Modified Appetitive Behavior / drug effects Appetitive Behavior / physiology* CD8 Antigens / genetics Drosophila Proteins / genetics Drosophila melanogaster Embryo, Nonmammalian Enzyme Inhibitors / pharmacology Gene Expression Regulation, Developmental / drug effects Gene Expression Regulation, Developmental / physiology Hydroxyurea / pharmacology Larva / physiology* Memory / physiology* Models, Biological Mushroom Bodies / cytology* Mushroom Bodies / embryology Neurons / drug effects Neurons / physiology* Olfactory Pathways / drug effects Olfactory Pathways / physiology* Smell / drug effects Smell / genetics Smell / physiology Statistics, Nonparametric Synapses / metabolism Transcription Factors / genetics |
| IF | 5.674 |
| 引用数 | 59 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| ショウジョウバエ | NP lines |