論文 - 詳細
| RRC ID | 11697 |
|---|---|
| 著者 | Abreu-Blanco MT, Verboon JM, Parkhurst SM. |
| タイトル | Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. |
| ジャーナル | J Cell Biol |
| Abstract |
When single cells or tissues are injured, the wound must be repaired quickly in order to prevent cell death, loss of tissue integrity, and invasion by microorganisms. We describe Drosophila as a genetically tractable model to dissect the mechanisms of single-cell wound repair. By analyzing the expression and the effects of perturbations of actin, myosin, microtubules, E-cadherin, and the plasma membrane, we define three distinct phases in the repair process-expansion, contraction, and closure-and identify specific components required during each phase. Specifically, plasma membrane mobilization and assembly of a contractile actomyosin ring are required for this process. In addition, E-cadherin accumulates at the wound edge, and wound expansion is excessive in E-cadherin mutants, suggesting a role for E-cadherin in anchoring the actomyosin ring to the plasma membrane. Our results show that single-cell wound repair requires specific spatial and temporal cytoskeleton responses with distinct components and mechanisms required at different stages of the process. |
| 巻・号 | 193(3) |
| ページ | 455-64 |
| 公開日 | 2011-5-2 |
| DOI | 10.1083/jcb.201011018 |
| PII | jcb.201011018 |
| PMID | 21518790 |
| PMC | PMC3087011 |
| MeSH | Actins / metabolism Actomyosin / chemistry Alleles Animals Animals, Genetically Modified Cadherins / metabolism Cell Membrane / metabolism* Crosses, Genetic Cytoskeleton / metabolism* Drosophila melanogaster / metabolism* Microtubules / metabolism Mutation Myosins / metabolism Wound Healing |
| IF | 8.811 |
| 引用数 | 74 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | ubi-DE-cadherin-GFP |