| RRC ID |
11706
|
| 著者 |
Keene AC, Mazzoni EO, Zhen J, Younger MA, Yamaguchi S, Blau J, Desplan C, Sprecher SG.
|
| タイトル |
Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment.
|
| ジャーナル |
J Neurosci
|
| Abstract |
Visual organs perceive environmental stimuli required for rapid initiation of behaviors and can also entrain the circadian clock. The larval eye of Drosophila is capable of both functions. Each eye contains only 12 photoreceptors (PRs), which can be subdivided into two subtypes. Four PRs express blue-sensitive rhodopsin5 (rh5) and eight express green-sensitive rhodopsin6 (rh6). We found that either PR-subtype is sufficient to entrain the molecular clock by light, while only the Rh5-PR subtype is essential for light avoidance. Acetylcholine released from PRs confers both functions. Both subtypes of larval PRs innervate the main circadian pacemaker neurons of the larva, the neuropeptide PDF (pigment-dispersing factor)-expressing lateral neurons (LNs), providing sensory input to control circadian rhythms. However, we show that PDF-expressing LNs are dispensable for light avoidance, and a distinct set of three clock neurons is required. Thus we have identified distinct sensory and central circuitry regulating light avoidance behavior and clock entrainment. Our findings provide insights into the coding of sensory information for distinct behavioral functions and the underlying molecular and neuronal circuitry.
|
| 巻・号 |
31(17)
|
| ページ |
6527-34
|
| 公開日 |
2011-4-27
|
| DOI |
10.1523/JNEUROSCI.6165-10.2011
|
| PII |
31/17/6527
|
| PMID |
21525293
|
| PMC |
PMC3103866
|
| MeSH |
Acetylcholine / metabolism
Analysis of Variance
Animals
Animals, Genetically Modified
Behavior, Animal / physiology
Circadian Clocks / physiology*
Drosophila
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Escape Reaction / physiology*
Eye Proteins / metabolism
Larva / physiology*
Light / adverse effects*
Light Signal Transduction
Luminescent Proteins / genetics
Microscopy, Confocal / methods
Mutation / genetics
Neurons / metabolism
Neuropeptides / genetics
Neuropeptides / metabolism
Neuropil / physiology
Photoreceptor Cells, Invertebrate / classification
Photoreceptor Cells, Invertebrate / physiology*
Rhodopsin / genetics
Visual Pathways / physiology*
|
| IF |
5.674
|
| 引用数 |
44
|
|
WOS 分野
|
NEUROSCIENCES
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| リソース情報 |
| ショウジョウバエ |
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