RRC ID 11761
著者 Koyama M, Kinkhabwala A, Satou C, Higashijima S, Fetcho J.
タイトル Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain.
ジャーナル Proc Natl Acad Sci U S A
Abstract The hindbrain of larval zebrafish contains a relatively simple ground plan in which the neurons throughout it are arranged into stripes that represent broad neuronal classes that differ in transmitter identity, morphology, and transcription factor expression. Within the stripes, neurons are stacked continuously according to age as well as structural and functional properties, such as axonal extent, input resistance, and the speed at which they are recruited during movements. Here we address the question of how particular networks among the many different sensory-motor networks in hindbrain arise from such an orderly plan. We use a combination of transgenic lines and pairwise patch recording to identify excitatory and inhibitory interneurons in the hindbrain network for escape behaviors initiated by the Mauthner cell. We map this network onto the ground plan to show that an individual hindbrain network is built by drawing components in predictable ways from the underlying broad patterning of cell types stacked within stripes according to their age and structural and functional properties. Many different specialized hindbrain networks may arise similarly from a simple early patterning.
巻・号 108(3)
ページ 1170-5
公開日 2011-1-18
DOI 10.1073/pnas.1012189108
PII 1012189108
PMID 21199937
PMC PMC3024692
MeSH Animals Animals, Genetically Modified Body Patterning / physiology* Brain Mapping / methods* Electrophysiology Escape Reaction / physiology* Image Processing, Computer-Assisted Immunohistochemistry Interneurons / metabolism Larva / anatomy & histology Larva / physiology Nerve Net* Patch-Clamp Techniques Psychomotor Performance / physiology Rhombencephalon / anatomy & histology Rhombencephalon / physiology* Zebrafish / anatomy & histology Zebrafish / physiology*
IF 9.412
引用数 84
WOS 分野 NEUROSCIENCES
リソース情報
ゼブラフィッシュ Tg(vglut2a:GFP) Tg(vglut2a:loxP-DsRed-loxP-GFP)