| RRC ID |
11771
|
| Author |
Takahashi E, Niimi K, Itakura C.
|
| Title |
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
|
| Journal |
Behav Brain Res
|
| Abstract |
Aged heterozygous Rolling Nagoya mice carrying Cav2.1alpha1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1alpha1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances.
|
| Volume |
204(1)
|
| Pages |
241-5
|
| Published |
2009-12-1
|
| DOI |
10.1016/j.bbr.2009.05.020
|
| PII |
S0166-4328(09)00334-9
|
| PMID |
19467269
|
| MeSH |
Aging*
Analysis of Variance
Animals
Calcium Channels, N-Type / genetics
Calcium Channels, N-Type / metabolism*
Genotype
Hippocampus / physiology*
Hippocampus / physiopathology
Male
Memory Disorders / physiopathology
Memory, Short-Term / physiology*
Mice
Mice, Mutant Strains
Mutation
Neuropsychological Tests
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Space Perception / physiology*
Temporal Lobe / physiology*
Temporal Lobe / physiopathology
|
| IF |
2.977
|
| Times Cited |
4
|
|
WOS Category
|
NEUROSCIENCES
BEHAVIORAL SCIENCES
|
| Resource |
| Mice |
RBRC00388 |
