| RRC ID |
11775
|
| 著者 |
Nishida K, Hasegawa A, Nakae S, Oboki K, Saito H, Yamasaki S, Hirano T.
|
| タイトル |
Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.
|
| ジャーナル |
J Exp Med
|
| Abstract |
Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency. However, it remains unknown how Zn homeostasis is regulated in mast cells and if Zn transporters are involved in allergic reactions. We show that Znt5/Slc30a5 is required for contact hypersensitivity and mast cell-mediated delayed-type allergic response but not for immediate passive cutaneous anaphylaxis. In mast cells from Znt5(-/-) mice, Fc epsilon receptor I (Fc epsilonRI)-induced cytokine production was diminished, but degranulation was intact. Znt5 was involved in Fc epsilonRI-induced translocation of protein kinase C (PKC) to the plasma membrane and the nuclear translocation of nuclear factor kappaB. In addition, the Zn finger-like motif of PKC was required for its plasma membrane translocation and binding to diacylglycerol. Thus, Znt5 is selectively required for the mast cell-mediated delayed-type allergic response, and it is a novel player in mast cell activation.
|
| 巻・号 |
206(6)
|
| ページ |
1351-64
|
| 公開日 |
2009-6-8
|
| DOI |
10.1084/jem.20082533
|
| PII |
jem.20082533
|
| PMID |
19451265
|
| PMC |
PMC2715059
|
| MeSH |
Amino Acid Sequence
Animals
Biological Transport
Cation Transport Proteins
Cell Degranulation / immunology
Cell Membrane / metabolism
Cells, Cultured
Cytokines / immunology
Dermatitis, Contact / immunology*
Hypersensitivity, Delayed / immunology*
Hypersensitivity, Immediate / immunology*
Isoenzymes / genetics
Isoenzymes / metabolism
Mast Cells / cytology
Mast Cells / immunology*
Membrane Transport Proteins / genetics
Membrane Transport Proteins / immunology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular Sequence Data
NF-kappa B / immunology
Passive Cutaneous Anaphylaxis / immunology*
Protein Kinase C / genetics
Protein Kinase C / metabolism
Receptors, IgE / immunology
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / immunology
Sequence Alignment
Signal Transduction / physiology
Zinc / immunology*
|
| IF |
11.743
|
| 引用数 |
69
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
IMMUNOLOGY
|
| リソース情報 |
| 実験動物マウス |
|
