RRC ID 11837
Author Chen CM, Wang HY, You LR, Shang RL, Liu FC.
Title Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.
Journal Dev. Dyn.
Abstract We report the expression of the mouse Mpped1 in the telencephalon through embryonic stages to adulthood. Using Northern blotting analysis and RNA in situ hybridization (ISH), our data show that Mpped1 is specifically expressed in the brain and is enriched in the cortical plate of the developing telencephalon. Postnatally, the expression of Mpped1 is reduced in the cerebral cortex relative to its levels in the embryonic dorsal telencephalon. Also, Mpped1 expression is sustained in the hippocampal CA1 region. Examination of the expression of Mpped1 and other cortical layer markers by ISH in a malformed beta-catenin null dorsal telencephalon show that the Mpped1-, Cux2-, and Rorbeta-expressing superficial cortical layers are reduced and form patchy patterns, and the Tbr-1-expressing deep-layer neurons are incorrectly located on superficial layers, indicative of a migration defect of cortical neurons in the absence of beta-catenin.
Volume 239(6)
Pages 1797-806
Published 2010-6
DOI 10.1002/dvdy.22293
PMID 20503375
MeSH Animals Blotting, Northern CA1 Region, Hippocampal Cerebral Cortex / embryology Cerebral Cortex / metabolism Embryo, Mammalian Female Genes Mice Mice, Congenic Mice, Inbred C57BL Mice, Inbred ICR Mice, Transgenic Neurons / metabolism Pregnancy Telencephalon / metabolism* beta Catenin / genetics* beta Catenin / metabolism
IF 2.852
Times Cited 6
Mice Emx1-Cre Tg1