論文 - 詳細
| RRC ID | 1192 |
|---|---|
| 著者 | Odashima M, Otaka M, Jin M, Konishi N, Sato T, Kato S, Matsuhashi T, Nakamura C, Watanabe S. |
| タイトル | Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine. |
| ジャーナル | Dig Dis Sci |
| Abstract |
An antiulcer drug, zinc L-carnosine (polaprezinc), provides gastric mucosal protection against various irritants. In this study, we evaluated the effects of zinc L-carnosine on expression of 72-kDa heat shock protein (HSP72, stress inducible HSP70), which is known as an endogenous cytoprotectant in a wide variety of cells, including rat gastric mucosa in vitro and in vivo. Expression of HSP72 after exposure to zinc L-carnosine, zinc sulfate, or L-carnosine (1-300 microM) in rat gastric mucosal cells (RGM1) and intragastric administration of zinc L-carnosine, zinc sulfate (30 or 100 mg/kg) and L-carnosine (76 mg/kg) was investigated by western blotting and densitometric analysis. Exposure to zinc L-carnosine and zinc sulfate increased the expression of HSP72 significantly in RGM1 cells. Intragastric administration of zinc L-carnosine and zinc sulfate showed significant increment in HSP72 in rat gastric mucosa also in vivo. The ability to induce HSP72 is significantly higher in zinc L-carnosine compared with zinc sulfate based on molecular concentration in vivo. However, L-carnosine did not increase the expression of HSP72 in vitro and in vivo. Zinc derivatives, especially zinc L-carnosine, could be a strong HSP72 (chaperon) inducer, which has been known to enhance mucosal protective ability. |
| 巻・号 | 47(12) |
| ページ | 2799-804 |
| 公開日 | 2002-12-1 |
| DOI | 10.1023/a:1021029927386 |
| PMID | 12498304 |
| MeSH | Animals Carnosine / analogs & derivatives* Carnosine / pharmacology* Cells, Cultured Gastric Mucins / metabolism* Gastric Mucosa / metabolism* HSP72 Heat-Shock Proteins Heat-Shock Proteins / metabolism* Male Organometallic Compounds / pharmacology* Rats Rats, Sprague-Dawley Zinc Zinc Compounds Zinc Sulfate / pharmacology |
| IF | 2.751 |
| 引用数 | 60 |
| WOS 分野 | GASTROENTEROLOGY & HEPATOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RGM1(RCB0876) |