RRC ID 12079
Author Hill AJ, Teraoka H, Heideman W, Peterson RE.
Title Zebrafish as a model vertebrate for investigating chemical toxicity.
Journal Toxicol. Sci.
Abstract Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity are highlighted.
Volume 86(1)
Pages 6-19
Published 2005-7
DOI 10.1093/toxsci/kfi110
PII kfi110
PMID 15703261
MeSH Animals Cells, Cultured Models, Animal* Oligonucleotide Array Sequence Analysis Toxicity Tests* Zebrafish / embryology Zebrafish / genetics
IF 4.181
Times Cited 507
Zebrafish Review