論文 - 詳細
| RRC ID | 12079 |
|---|---|
| 著者 | Hill AJ, Teraoka H, Heideman W, Peterson RE. |
| タイトル | Zebrafish as a model vertebrate for investigating chemical toxicity. |
| ジャーナル | Toxicol Sci |
| Abstract |
Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity are highlighted. |
| 巻・号 | 86(1) |
| ページ | 6-19 |
| 公開日 | 2005-7-1 |
| DOI | 10.1093/toxsci/kfi110 |
| PII | kfi110 |
| PMID | 15703261 |
| MeSH | Animals Cells, Cultured Models, Animal* Oligonucleotide Array Sequence Analysis Toxicity Tests* Zebrafish / embryology Zebrafish / genetics |
| IF | 3.703 |
| 引用数 | 762 |
| WOS 分野 | TOXICOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Review |