RRC ID 12140
Author Schuster K, Dambly-Chaudière C, Ghysen A.
Title Glial cell line-derived neurotrophic factor defines the path of developing and regenerating axons in the lateral line system of zebrafish.
Journal Proc. Natl. Acad. Sci. U.S.A.
Abstract How the peripheral axons of sensory neurons are guided to distant target organs is not well understood. Here we examine this question in the case of the posterior lateral line (PLL) system of zebrafish, where sensory organs are deposited by a migrating primordium. Sensory neurites accompany this primordium during its migration and are thereby guided to their prospective target organs. We show that the inactivation of glial cell line-derived neurotrophic factor (GDNF) signaling leads to defects of innervation and that these defects are due to the inability of sensory axons to track the migrating primordium. GDNF signaling is also used as a guidance cue during axonal regeneration following nerve cut. We conclude that GDNF is a major determinant of directed neuritic growth and of target finding in this system, and we propose that GDNF acts by promoting local neurite outgrowth.
Volume 107(45)
Pages 19531-6
Published 2010-11-9
DOI 10.1073/pnas.1002171107
PII 1002171107
PMID 20974953
PMC PMC2984216
MeSH Animals Axons / physiology* Glial Cell Line-Derived Neurotrophic Factor / physiology* Lateral Line System / physiology* Nerve Regeneration / physiology* Neurites Sensory Receptor Cells Signal Transduction / physiology Synaptic Transmission Zebrafish
IF 9.58
Times Cited 19
Zebrafish rw0130a (Tg (Huc:Kaede))