| RRC ID |
12141
|
| Author |
Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H.
|
| Title |
Filtering of visual information in the tectum by an identified neural circuit.
|
| Journal |
Science
|
| Abstract |
The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter γ-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.
|
| Volume |
330(6004)
|
| Pages |
669-73
|
| Published |
2010-10-29
|
| DOI |
10.1126/science.1192949
|
| PII |
330/6004/669
|
| PMID |
21030657
|
| PMC |
PMC3243732
|
| MeSH |
Animals
Animals, Genetically Modified
Axons / physiology
Bicuculline / pharmacology
Dendrites / physiology
GABA Antagonists / pharmacology
Interneurons / physiology*
Neural Inhibition
Neurons / physiology*
Neuropil / physiology
Optic Lobe, Nonmammalian / cytology
Optic Lobe, Nonmammalian / physiology*
Photic Stimulation
Retina / physiology*
Retinal Neurons / physiology
Synaptic Transmission
Visual Pathways / physiology*
Visual Perception*
Zebrafish
gamma-Aminobutyric Acid / metabolism
|
| IF |
41.846
|
| Times Cited |
144
|
|
WOS Category
|
NEUROSCIENCES
|
| Resource |
| Zebrafish |
Tol2
TeTxLC-CFP |
