| RRC ID |
12158
|
| Author |
Hirashima Y, Ueno H, Karasawa K, Yokoyama K, Setaka M, Takaku A.
|
| Title |
Transfection of the plasma-type platelet-activating factor acetylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons.
|
| Journal |
Brain Res
|
| Abstract |
Using an adenoviral vector, we induced overexpression of the plasma type of platelet-activating factor acetylhydrolase in cultured rat neurons. Neurons overexpressing this enzyme showed a decrease in glutamate-induced injury, mainly, apparent as decreased apoptosis. Reduction of lipid peroxidation by this enzyme and protection of mitochondrial function were demonstrated, and these may be the basis of the resistance to glutamate-induced neuronal injury that we observed.
|
| Volume |
885(1)
|
| Pages |
128-32
|
| Published |
2000-12-1
|
| DOI |
10.1016/s0006-8993(00)02852-3
|
| PII |
S0006-8993(00)02852-3
|
| PMID |
11121539
|
| MeSH |
1-Alkyl-2-acetylglycerophosphocholine Esterase
Adenoviridae / genetics
Animals
Apoptosis / drug effects
Apoptosis / physiology*
Cells, Cultured
Cerebral Cortex / cytology
Genetic Vectors
Glutamic Acid / pharmacology
Guinea Pigs
Lac Operon
Malondialdehyde / metabolism
Mitochondria / metabolism
Neurons / cytology*
Neurons / enzymology*
Phospholipases A / genetics*
Rats
Transfection
|
| IF |
2.733
|
| Times Cited |
16
|
|
WOS Category
|
NEUROSCIENCES
|
| Resource |
| DNA material |
Ax1w1 (RDB01746)
AxCANLacZ (RDB03211). |
