Reference - Detail
| RRC ID | 12194 |
|---|---|
| Author | Motoki Y, Tamura H, Watanabe T, Suga T. |
| Title | Wy-14,643, a peroxisome proliferator, inhibits compensative cell proliferation and hepatocyte growth factor mRNA expression in the rat liver. |
| Journal | Cancer Lett |
| Abstract |
Previously, we found that a peroxisome proliferator significantly reduced hepatic and plasma hepatocyte growth factor (HGF) levels in male F-344 rats, and that the growth of preneoplastic or neoplastic cells induced by this peroxisome proliferator was markedly inhibited by HGF. Here, we examined the effects of [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643), a peroxisome proliferator, on cell proliferation and HGF mRNA levels in the liver of rats after stimulation of compensative cell proliferation. After 2 weeks of treatment with Wy-14,643, hepatic DNA synthesis caused by partial hepatectomy was decreased by 50% compared with untreated controls. DNA synthesis was maintained at the same reduced level for up to 10 weeks. During this period, hepatic HGF mRNA level was also much lower in Wy-14,643-treated rats than untreated controls. Therefore Wy-14,643, a peroxisome proliferator, would inhibit the growth of normal hepatocytes, and then produce an advantageous circumstance for the selective growth of neoplastic or preneoplastic cells. |
| Volume | 135(2) |
| Pages | 145-50 |
| Published | 1999-1-29 |
| DOI | 10.1016/s0304-3835(98)00287-0 |
| PII | S0304-3835(98)00287-0 |
| PMID | 10096422 |
| MeSH | Animals Carcinogens / pharmacology* Cell Division / drug effects Hepatectomy Hepatocyte Growth Factor / metabolism* Liver / drug effects* Liver / metabolism Liver / pathology Male Peroxisome Proliferators / pharmacology* Pyrimidines / pharmacology* RNA, Messenger / drug effects* RNA, Messenger / metabolism Rats Rats, Inbred F344 Time Factors |
| IF | 7.36 |
| Times Cited | 1 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pRBC1 (RDB01194) |