論文 - 詳細
| RRC ID | 12339 |
|---|---|
| 著者 | Miyashita M, Oda M, Ono Y, Komoda E, Miyagawa H. |
| タイトル | Discovery of a small peptide from combinatorial libraries that can activate the plant immune system by a jasmonic acid signaling pathway. |
| ジャーナル | Chembiochem |
| Abstract |
Plants defend themselves by using an innate immune system that is activated in response to a variety of molecules derived from pathogens. These molecules have provided profound insights into the mechanisms of pathogen recognition and subsequent signaling pathways in plants. In the present study, we screened a combinatorial random hexapeptide library for peptides that activate the plant immune system, by using a cell-based high-throughput screening system in which H(2)O(2) generation was monitored. We discovered a novel small peptide (YGIHTH-amide, PIP-1) that triggered H(2)O(2) production in tobacco and tomato cells, but not in Arabidopsis cells. PIP-1 induced significant levels of phytoalexin biosynthesis and defense-related gene expression in tobacco cells; this is likely to be activated by a jasmonic acid pathway. |
| 巻・号 | 12(9) |
| ページ | 1323-9 |
| 公開日 | 2011-6-14 |
| DOI | 10.1002/cbic.201000694 |
| PMID | 21567702 |
| MeSH | Amino Acid Sequence Arabidopsis / chemistry Arabidopsis / metabolism* Combinatorial Chemistry Techniques Cyclopentanes / metabolism* Hydrogen Peroxide / chemistry Hydrogen Peroxide / metabolism Immunity, Innate* / drug effects Lycopersicon esculentum / chemistry Molecular Sequence Data Oligopeptides / chemistry Oligopeptides / genetics Oligopeptides / metabolism* Oligopeptides / pharmacology Oxylipins / metabolism* Plant Immunity* / drug effects Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / drug effects Small Molecule Libraries* / chemistry Structure-Activity Relationship Tobacco / chemistry |
| IF | 2.576 |
| 引用数 | 9 |
| WOS 分野 | CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | rpc00012 |