Reference - Detail
RRC ID | 12424 |
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Author | Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N. |
Title | Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. |
Journal | Oncol Res |
Abstract |
The properties and effects of neutral pH hydrogen-enriched electrolyzed water (NHE water) on tumor cells were examined. NHE water diminished hydroxyl radicals as demonstrated by ESR in a cell-free system. Human tongue carcinoma cells HSC-4 were inhibited for either colony formation efficiencies or colony sizes by NHE water without significant inhibition to normal human tongue epithelial-like cells DOK. Furthermore, NHE water caused growth inhibition, cell degeneration, and inhibition of invasion through the reconstituted basement membrane to human fibrosarcoma cells HT-1080. Intracellular oxidants such as hydroperoxides and hydrogen peroxides were scavenged in HSC-4 or HT-1080 cells by NHE water. In the human oral cavity, a dissolved hydrogen concentrations (DH) of NHE water was drastically declined from 1.1 to 0.5 ppm, but settled to 0.3-0.4 ppm until 180 s, upon static holding without gargling. Thus, NHE water was shown to achieve tumor-preferential growth inhibition and tumor invasion together with scavenging of intracellular oxidants, and is expected as a preventive material against tumor progression and invasion. |
Volume | 17(6) |
Pages | 247-55 |
Published | 2008-1-1 |
DOI | 10.3727/096504008786991620 |
PMID | 19192719 |
MeSH | Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects* Cells, Cultured Electrolysis Epithelial Cells / cytology Epithelial Cells / drug effects Epithelial Cells / metabolism Free Radical Scavengers / chemistry Free Radical Scavengers / pharmacology Humans Hydrogen / chemistry* Hydrogen-Ion Concentration Hydroxyl Radical / chemistry Hydroxyl Radical / metabolism Neoplasm Invasiveness / prevention & control Oxidants / metabolism* Reactive Oxygen Species / chemistry Reactive Oxygen Species / metabolism Tongue / cytology Water / chemistry Water / pharmacology* |
IF | 4.949 |
Times Cited | 31 |
WOS Category | ONCOLOGY |
Resource | |
Human and Animal Cells |