| RRC ID |
1248
|
| Author |
Nishikawa K, Satoh H, Hirai A, Suzuzki K, Asano R, Kumadaki I, Hagiwara K, Yano T.
|
| Title |
alpha-Tocopheryloxybutyric acid enhances necrotic cell death in breast cancer cells treated with chemotherapy agent.
|
| Journal |
Cancer Lett
|
| Abstract |
The overexpression of HER-2 receptor contributes to malignant transformation of breast cancer cells. We have reported that alpha-tocopheryloxybutyric acid (TE), non-antioxidative vitamin E ether derivative inhibits the activation of HER-2 receptor. The present study was undertaken to estimate if TE could act as a useful anti-cancer agent against a breast cancer cell overexpressing HER-2 receptor (MDA-MB-453 cell line) in combination with a conventional chemotherapy agent, adriamycin (ADR). TE enhanced cytotoxic effect of ADR against the human breast cancer cell at low doses less than IC(50). The enhancing effect was mainly dependent on the elevation of necrotic-like cell death but not apoptotic cell death. In conjugation with this event, the inactivation of HER-2 receptor in the breast cancer cell was caused by the combination of TE with ADR. These results suggest that TE enhances necrotic-like cell death in the breast cancer cells and that the cell death relates to the inactivation of HER-2 receptor in the breast cancer cells.
|
| Volume |
201(1)
|
| Pages |
51-6
|
| Published |
2003-11-10
|
| DOI |
10.1016/s0304-3835(03)00462-2
|
| PII |
S0304383503004622
|
| PMID |
14580686
|
| MeSH |
Antibiotics, Antineoplastic / pharmacology
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology*
Cell Line, Tumor
Dose-Response Relationship, Drug
Doxorubicin / pharmacology
Humans
Immunoblotting
Necrosis
Protein Serine-Threonine Kinases*
Proto-Oncogene Proteins / drug effects
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-akt
Receptor, ErbB-3 / drug effects
Receptor, ErbB-3 / metabolism
Vitamin E / analogs & derivatives*
Vitamin E / pharmacology*
|
| IF |
7.36
|
| Times Cited |
14
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
MDA-MB-453(RCB1192) |
