論文 - 詳細
| RRC ID | 1259 |
|---|---|
| 著者 | Iwata K, Ogata S, Okumura K, Taguchi H. |
| タイトル | Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotinamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation. |
| 巻・号 | 67(8) |
| ページ | 1836-9 |
| 公開日 | 2003-8-1 |
| DOI | 10.1271/bbb.67.1836 |
| PMID | 12951526 |
| MeSH | ADP-ribosyl Cyclase / biosynthesis* ADP-ribosyl Cyclase / metabolism ADP-ribosyl Cyclase 1 Antigens, CD / biosynthesis* Antigens, CD / metabolism Cell Differentiation / drug effects Cell Differentiation / physiology Cell Membrane / metabolism Flow Cytometry Gene Expression / drug effects* HL-60 Cells Humans Isonicotinic Acids / pharmacology* Membrane Glycoproteins Niacinamide / analogs & derivatives* Niacinamide / pharmacology Tretinoin / metabolism Tretinoin / pharmacology |
| IF | 1.516 |
| 引用数 | 6 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |