論文 - 詳細
| RRC ID | 12626 |
|---|---|
| 著者 | Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, Inui H. |
| タイトル | A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Androgenic compounds induce an interaction between the NH(2)- and COOH-terminal regions (N-C interaction) of androgen receptor (AR). We describe a rapid yeast bioassay for androgenic and anti-androgenic compounds based on androgen-dependent β-catenin-enhanced N-C interaction. The bioassay was also effective at detecting compounds that inhibit the N-C interaction in ways that do not involve binding to the ligand-binding domain. |
| 巻・号 | 74(9) |
| ページ | 1965-8 |
| 公開日 | 2010-1-1 |
| DOI | 10.1271/bbb.100323 |
| PII | JST.JSTAGE/bbb/100323 |
| PMID | 20834141 |
| MeSH | Androgen Antagonists / analysis* Androgens / analysis* Animals Drug Evaluation, Preclinical / methods* Humans Receptors, Androgen / chemistry* Receptors, Androgen / metabolism Yeasts beta Catenin |
| IF | 1.516 |
| 引用数 | 2 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 酵母 | YPH499? |