論文 - 詳細
| RRC ID | 1317 |
|---|---|
| 著者 | Nishimura H, Nishimura M, Oda R, Yamanaka K, Matsubara T, Ozaki Y, Sekiya K, Hamada T, Kato Y. |
| タイトル | Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds. |
| ジャーナル | Exp Cell Res |
| Abstract |
Transplantation of bone marrow mesenchymal stem cells (MSC), chondrocytes, osteoblasts, or muscle cells promotes regeneration. However, these cells adhere poorly to some scaffolds--depending upon the scaffold material--and are often damaged by proteases or mechanical stimuli at site of transplantation. We found, however, that MSC, chondrocytes, and osteoblasts--along with some other cells--that were exposed to phaseolus vulgaris erythroagglutinin (PHA-E) or concanavalin A (ConA) increased their adhesion capacity on plastic tissue culture dishes and on plates of hydroxyapatite, titanium and poly-DL-lactic-co-glycolic acid (PLGA), and that these cells, moreover, built up resistance to proteases and/or mechanical stimuli. Thus, lectins may have great potential in tissue engineering and cell therapy. |
| 巻・号 | 295(1) |
| ページ | 119-27 |
| 公開日 | 2004-4-15 |
| DOI | 10.1016/j.yexcr.2003.12.018 |
| PII | S0014482704000035 |
| PMID | 15051495 |
| MeSH | Animals Bone Marrow Cells / cytology Bone Marrow Cells / drug effects Bone Marrow Cells / physiology* Cell Movement / drug effects Cell Movement / physiology Cells, Cultured Concanavalin A / pharmacology Endopeptidases / metabolism* Femur Humans Ilium Kinetics Lectins / pharmacology* Matrix Attachment Regions / physiology* Mesoderm / cytology Mesoderm / drug effects Mesoderm / physiology* Protease Inhibitors / pharmacology Rabbits Stem Cells / cytology Stem Cells / drug effects Stem Cells / physiology* |
| IF | 3.383 |
| 引用数 | 10 |
| WOS 分野 | ONCOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) MC3T3-E1(RCB1126) 10T1/2(RCB0247) C2C12(RCB0987) MC3T3-G2/PA6(RCB1127) |