RRC ID |
1472
|
著者 |
Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T.
|
タイトル |
Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.
|
ジャーナル |
FEBS Lett
|
Abstract |
It has been assumed that prostaglandin (PG)I2 signaling contributes to the negative growth control of lung cancer cells; however, the mechanism remains unresolved. PGI2 functions through a cell surface G protein-coupled receptor (prostaglandin I2-binding receptor, IP) and also exerts an effect by interacting with a nuclear hormone receptor, peroxisome proliferator-activated receptor delta (PPARdelta). We found that PPARdelta was a key molecule of PGI2 signaling to give negative growth control of lung cancer cells (A549), using carbarprostacyclin, a PGI2 agonist for IP and PPARdelta, and L-165041, a PPARdelta agonist. Furthermore, PPARdelta-induced cell growth control was reinforced by the inhibition of cyclooxygenase. These results suggest that PPARdelta activation under the suppression of PG synthesis is important to regulate lung cancer cell growth.
|
巻・号 |
579(17)
|
ページ |
3829-36
|
公開日 |
2005-7-4
|
DOI |
10.1016/j.febslet.2005.06.004
|
PII |
S0014-5793(05)00714-3
|
PMID |
15978581
|
MeSH |
Apoptosis
Down-Regulation
Epoprostenol / agonists
Epoprostenol / metabolism*
Epoprostenol / pharmacology
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / metabolism*
PPAR delta / agonists
PPAR delta / antagonists & inhibitors
PPAR delta / metabolism*
RNA, Small Interfering / genetics
RNA, Small Interfering / pharmacology
Receptors, Epoprostenol / genetics
Receptors, Epoprostenol / metabolism*
Signal Transduction
Tumor Cells, Cultured
Up-Regulation
|
IF |
3.057
|
引用数 |
52
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
A549(RCB0098) |