論文 - 詳細
| RRC ID | 1472 |
|---|---|
| 著者 | Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T. |
| タイトル | Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth. |
| ジャーナル | FEBS Lett |
| Abstract |
It has been assumed that prostaglandin (PG)I2 signaling contributes to the negative growth control of lung cancer cells; however, the mechanism remains unresolved. PGI2 functions through a cell surface G protein-coupled receptor (prostaglandin I2-binding receptor, IP) and also exerts an effect by interacting with a nuclear hormone receptor, peroxisome proliferator-activated receptor delta (PPARdelta). We found that PPARdelta was a key molecule of PGI2 signaling to give negative growth control of lung cancer cells (A549), using carbarprostacyclin, a PGI2 agonist for IP and PPARdelta, and L-165041, a PPARdelta agonist. Furthermore, PPARdelta-induced cell growth control was reinforced by the inhibition of cyclooxygenase. These results suggest that PPARdelta activation under the suppression of PG synthesis is important to regulate lung cancer cell growth. |
| 巻・号 | 579(17) |
| ページ | 3829-36 |
| 公開日 | 2005-7-4 |
| DOI | 10.1016/j.febslet.2005.06.004 |
| PII | S0014-5793(05)00714-3 |
| PMID | 15978581 |
| MeSH | Apoptosis Down-Regulation Epoprostenol / agonists Epoprostenol / metabolism* Epoprostenol / pharmacology Humans Lung Neoplasms / drug therapy Lung Neoplasms / metabolism* PPAR delta / agonists PPAR delta / antagonists & inhibitors PPAR delta / metabolism* RNA, Small Interfering / genetics RNA, Small Interfering / pharmacology Receptors, Epoprostenol / genetics Receptors, Epoprostenol / metabolism* Signal Transduction Tumor Cells, Cultured Up-Regulation |
| IF | 3.057 |
| 引用数 | 52 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |