RRC ID 1472
著者 Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T.
タイトル Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.
ジャーナル FEBS Lett
Abstract It has been assumed that prostaglandin (PG)I2 signaling contributes to the negative growth control of lung cancer cells; however, the mechanism remains unresolved. PGI2 functions through a cell surface G protein-coupled receptor (prostaglandin I2-binding receptor, IP) and also exerts an effect by interacting with a nuclear hormone receptor, peroxisome proliferator-activated receptor delta (PPARdelta). We found that PPARdelta was a key molecule of PGI2 signaling to give negative growth control of lung cancer cells (A549), using carbarprostacyclin, a PGI2 agonist for IP and PPARdelta, and L-165041, a PPARdelta agonist. Furthermore, PPARdelta-induced cell growth control was reinforced by the inhibition of cyclooxygenase. These results suggest that PPARdelta activation under the suppression of PG synthesis is important to regulate lung cancer cell growth.
巻・号 579(17)
ページ 3829-36
公開日 2005-7-4
DOI 10.1016/j.febslet.2005.06.004
PII S0014-5793(05)00714-3
PMID 15978581
MeSH Apoptosis Down-Regulation Epoprostenol / agonists Epoprostenol / metabolism* Epoprostenol / pharmacology Humans Lung Neoplasms / drug therapy Lung Neoplasms / metabolism* PPAR delta / agonists PPAR delta / antagonists & inhibitors PPAR delta / metabolism* RNA, Small Interfering / genetics RNA, Small Interfering / pharmacology Receptors, Epoprostenol / genetics Receptors, Epoprostenol / metabolism* Signal Transduction Tumor Cells, Cultured Up-Regulation
IF 3.057
引用数 52
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ヒト・動物細胞 A549(RCB0098)