論文 - 詳細
| RRC ID | 1519 |
|---|---|
| 著者 | Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T. |
| タイトル | Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Myoblasts are able to differentiate into other mesenchymal lineages including adipocytes and osteoblasts. However, it is not known how this differentiation is normally regulated in intact animals and humans. Here, we subjected cultured C2C12 myoblasts to cyclic mechanical stretch (20% elongation) during differentiation into adipocytes. Mechanical stretch inhibited the myoblast-to-adipocyte differentiation significantly, concurrent with an enhanced expression of Wnt10b mRNA. Inhibition of the Wnt signaling by incubation of the myoblasts with a soluble Wnt ligand, sFRP-2, abolished the inhibitory function of mechanical stretch on adipogenesis. These findings provide evidence that mechanical stretch inhibits myoblast-to-adipocyte differentiation possibly through Wnt signaling. |
| 巻・号 | 329(1) |
| ページ | 381-5 |
| 公開日 | 2005-4-1 |
| DOI | 10.1016/j.bbrc.2005.01.136 |
| PII | S0006-291X(05)00122-1 |
| PMID | 15721317 |
| MeSH | Adipocytes / cytology* Adipocytes / metabolism Animals Azo Compounds / pharmacology Cell Differentiation Cell Line Cell Lineage Cell Membrane / metabolism Intercellular Signaling Peptides and Proteins / metabolism* Ligands Mice Myoblasts / cytology* RNA / metabolism RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Stress, Mechanical Wnt Proteins |
| IF | 2.985 |
| 引用数 | 47 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |