RRC ID 15403
著者 Naylor SA, DiAntonio A.
タイトル EGFR signaling modulates synaptic connectivity via Gurken.
ジャーナル Dev Neurobiol
Abstract Synaptic target selection is critical for establishing functional neuronal circuits. The mechanisms regulating target selection remain incompletely understood. We describe a role for the EGF receptor and its ligand Gurken in target selection of octopaminergic Type II neurons in the Drosophila neuromuscular system. Mutants in happyhour, a regulator of EGFR signaling, form ectopic Type II neuromuscular junctions. These ectopic innervations are due to inappropriate target selection. We demonstrate that EGFR signaling is necessary and sufficient to inhibit synaptic target selection by these octopaminergic Type II neurons, and that the EGFR ligand Gurken is the postsynaptic, muscle-derived repulsive cue. These results identify a new pathway mediating cell-type and branch-specific synaptic repulsion, a novel role for EGFR signaling in synaptic target selection, and an unexpected role for Gurken as a muscle-secreted repulsive ligand.
巻・号 72(9)
ページ 1229-42
公開日 2012-9-1
DOI 10.1002/dneu.20992
PMID 22021126
PMC PMC3687550
MeSH Animals Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster ErbB Receptors / physiology* Receptors, Invertebrate Peptide / physiology* Signal Transduction / physiology* Synaptic Transmission / physiology* Transforming Growth Factor alpha / metabolism Transforming Growth Factor alpha / physiology*
IF 3.935
引用数 1
WOS 分野 NEUROSCIENCES DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ the Drosophila Genetic Resource Center for fly lines.