Reference - Detail
| RRC ID | 15405 |
|---|---|
| Author | Goossens T, Kang YY, Wuytens G, Zimmermann P, Callaerts-Végh Z, Pollarolo G, Islam R, Hortsch M, Callaerts P. |
| Title | The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. |
| Journal | Development |
| Abstract |
The spatiotemporal integration of adhesion and signaling during neuritogenesis is an important prerequisite for the establishment of neuronal networks in the developing brain. In this study, we describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis. Selective axon bundling in the peduncle requires both the extracellular and the intracellular domain of NRG. We uncover a novel role for the ZO-1 homolog Polychaetoid (PYD) in axon branching and in sister branch outgrowth and guidance downstream of the neuron-specific isoform NRG-180. Furthermore, genetic analyses show that the role of NRG in different aspects of MB axonal development not only involves PYD, but also TRIO, SEMA-1A and RAC1. |
| Volume | 138(8) |
| Pages | 1595-605 |
| Published | 2011-4-1 |
| DOI | 10.1242/dev.052787 |
| PII | dev.052787 |
| PMID | 21389050 |
| PMC | PMC3062427 |
| MeSH | Animals Axons / metabolism* Axons / physiology Cell Adhesion Molecules, Neuronal / genetics Cell Adhesion Molecules, Neuronal / metabolism* Cell Line Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Female Immunohistochemistry Male Mushroom Bodies / cytology* Mushroom Bodies / metabolism* Neural Cell Adhesion Molecule L1 / genetics Neural Cell Adhesion Molecule L1 / metabolism* Organogenesis / genetics Organogenesis / physiology Polymerase Chain Reaction Signal Transduction / genetics Signal Transduction / physiology |
| IF | 5.611 |
| Times Cited | 19 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | pyd[LL04525] was obtained from the Drosophila Genetic Resource Center (Kyoto Japan). |