Reference - Detail
| RRC ID | 15572 |
|---|---|
| Author | Cáceres L, Necakov AS, Schwartz C, Kimber S, Roberts IJ, Krause HM. |
| Title | Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75. |
| Journal | Genes Dev |
| Abstract |
Nitric oxide gas acts as a short-range signaling molecule in a vast array of important physiological processes, many of which include major changes in gene expression. How these genomic responses are induced, however, is poorly understood. Here, using genetic and chemical manipulations, we show that nitric oxide is produced in the Drosophila prothoracic gland, where it acts via the nuclear receptor ecdysone-induced protein 75 (E75), reversing its ability to interfere with its heterodimer partner, Drosophila hormone receptor 3 (DHR3). Manipulation of these interactions leads to gross alterations in feeding behavior, fat deposition, and developmental timing. These neuroendocrine interactions and consequences appear to be conserved in vertebrates. |
| Volume | 25(14) |
| Pages | 1476-85 |
| Published | 2011-7-15 |
| DOI | 10.1101/gad.2064111 |
| PII | gad.2064111 |
| PMID | 21715559 |
| PMC | PMC3143938 |
| MeSH | Animals DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* DNA-Binding Proteins / pharmacology Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila Proteins / pharmacology Drosophila melanogaster / drug effects Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Drosophila melanogaster / physiology* Ecdysone / pharmacology Feeding Behavior / physiology Free Radical Scavengers / pharmacology Gene Expression Profiling Gene Expression Regulation, Developmental / drug effects Gene Knockdown Techniques Larva Lipid Metabolism Metamorphosis, Biological / genetics Metamorphosis, Biological / physiology Nitric Oxide / metabolism* Nitric Oxide / pharmacology RNA Interference Receptors, Cytoplasmic and Nuclear / metabolism Receptors, Steroid / metabolism Transcription Factors / genetics Transcription Factors / metabolism* Transcription Factors / pharmacology |
| IF | 9.527 |
| Times Cited | 76 |
| WOS Category | DEVELOPMENTAL BIOLOGY GENETICS & HEREDITY CELL BIOLOGY |
| Resource | |
| Drosophila | 12208R-2 12208R-3 6713R-1 6713R-3 |